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VOL. 1, ISSUE 1 (2025)
Evaluation of wound healing potential of cuttlefish bone extract: An experimental study
Authors
Anuja Nanasaheb Nikam
Abstract
Wound healing remains a significant clinical challenge, particularly in
cases of chronic wounds and delayed healing. This experimental study
investigates the therapeutic potential of cuttlefish bone extract (CBE) as a
novel wound healing agent. Trace amounts matrix proteins, has been
traditionally used in various medicinal applications. The study employed both in
vitro and in vivo experimental models to evaluate the wound
healing properties of CBE. Cell proliferation assays using human dermal
fibroblasts demonstrated enhanced cellular migration and proliferation rates
when treated with CBE concentrations ranging from 50-200 μg/mL. In vivo
studies using a rat excisional wound model showed accelerated wound closure,
improved re-epithelialization, and enhanced collagen deposition in CBE-treated
groups compared to controls. Histological analysis revealed increased
angiogenesis and reduced inflammatory infiltration in wounds treated with CBE.
The extract demonstrated antimicrobial activity against common wound pathogens,
including Staphylococcus aureus and Pseudomonas aeruginosa. These findings
suggest that cuttlefish bone extract possesses significant wound healing
potential through multiple mechanisms, including enhanced cellular
proliferation, improved angiogenesis, antimicrobial activity, and modulation of
inflammatory responses. Further clinical studies are warranted to validate
these promising preclinical results.
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Pages:6-10
How to cite this article:
Anuja Nanasaheb Nikam "Evaluation of wound healing potential of cuttlefish bone extract: An experimental study". World Journal of Education, Vol 1, Issue 1, 2025, Pages 6-10
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